Isotretinoin

Isotretinoin recalls: 16 FDA reports

Recalls involving Isotretinoin. What was wrong with each batch, and how the FDA graded the risk.

16Reports
0Class I
5Ongoing
2026-04-29Most recent

What the classes mean

The FDA sorts every recall into one of three classes. The class is the whole story. It is also the part people skip.

ClassWhat the FDA is saying
Class IThere is a reasonable probability that using this will cause serious harm or death.
Class IIIt may cause temporary or reversible harm. Serious harm is unlikely.
Class IIIIt breaks a rule but is unlikely to hurt anyone. Often a labelling fault.

Class II is the bulk of every list here. That matters. A long list of Class II says something different from one Class I.

By class

ClassReports
Class II10
Class III6

By year reported

YearReports
20151
20161
20177
20181
20191
20241
20264
Checking whether it affects you

The lot or code number is what matters. Not the product name. A recall covers specific lots. Yours may not be one of them.

Check the code on your package against the report. The FDA keeps the current list at fda.gov/safety/recalls.

The reports

The text below is quoted from the FDA record word for word.

Claravis (isotretinoin capsule, USP), 10 mg, Packaged as a) 100-count carton, NDC 0555-1054-56, with 10x10 bli

D-0521-2026  ·  Class II  ·  reported 2026-04-29  ·  Ongoing

Why it was recalled
Failed Impurities/Degradation Specifications: Out of specification for specific impurity Tretinoin
Product
Claravis (isotretinoin capsule, USP), 10 mg, Packaged as a) 100-count carton, NDC 0555-1054-56, with 10x10 blister packs NDC 0555-1054-60; b) 30-count carton, NDC 0555-1054-86, with 3X10 blister pack NDC 0555-1054-60; Rx only, Teva Pharmaceuticals USA, Inc., North Wales, PA 19454.
Where it went
Nationwide in the USA, Puerto Rico and Virgin Islands
How much
5,101 cartons

Isotretinoin Capsules, USP, 40 mg, 10 count Prescription Pacs, Rx only, Manufactured for: Teva Pharmaceuticals

D-0446-2026  ·  Class II  ·  reported 2026-04-15  ·  Ongoing

Why it was recalled
Superpotent and Subpotent
Product
Isotretinoin Capsules, USP, 40 mg, 10 count Prescription Pacs, Rx only, Manufactured for: Teva Pharmaceuticals USA, Inc., Parsippany, NJ 07054, NDC 0591-2436-15 (carton), NDC 0591-2436-45 (blister pack).
Where it went
FL, OH, PR & MS
How much
8376 packages

Isotretinoin Capsules, USP, 30 mg, Rx Only, 10 count Prescription Pack, Manufactured for: Teva Pharmaceuticals

D-0445-2026  ·  Class II  ·  reported 2026-04-15  ·  Ongoing

Why it was recalled
Superpotent and Subpotent
Product
Isotretinoin Capsules, USP, 30 mg, Rx Only, 10 count Prescription Pack, Manufactured for: Teva Pharmaceuticals USA, Inc., Parsippany, NJ 07054, NDC 0591-2435-15 (carton), NDC 0591-2435-45 (blister pack).
Where it went
FL, OH, PR & MS
How much
21984 packages

Amnesteem (Isotretinoin) Capsules, USP 40 mg, packaged in 3 x 10-Count Prescription Packs, Rx Only, Manufactur

D-0399-2026  ·  Class II  ·  reported 2026-03-11  ·  Ongoing

Why it was recalled
Failed Dissolution Specifications
Product
Amnesteem (Isotretinoin) Capsules, USP 40 mg, packaged in 3 x 10-Count Prescription Packs, Rx Only, Manufactured for: Mylan Pharmaceuticals Inc., Morgantown, WV, 26505 USA, Made in France, NDC 0378-6614-93.
Where it went
Nationwide within the United States
How much
34850 blister packs

Isotretinoin Capsules, USP 40mg, 30-count 3x10 blister packs per carton, Rx Only, Manufactured For: Teva Phar

D-0439-2024  ·  Class II  ·  reported 2024-04-17  ·  Ongoing

Why it was recalled
Superpotent Drug: The 3-month stability result for assay was found to be above specification limit
Product
Isotretinoin Capsules, USP 40mg, 30-count 3x10 blister packs per carton, Rx Only, Manufactured For: Teva Pharmaceuticals USA, Inc., Parsippany, NJ 07054. Blister Pack NDC 0591-2436-45, Carton NDC 0591-2436-15
Where it went
Nationwide in the USA
How much
5,304 3x10-cartons

Isotretinoin Capsules, USP 10 mg. Rx Only, 3 Prescription Blister Packs of 10- Capsules Each (30 Capsules)-. D

D-0321-2020  ·  Class III  ·  reported 2019-11-20  ·  Terminated

Why it was recalled
Failed Impurities/Degradation Specifications: Tretinoin levels slightly above specification limits.
Product
Isotretinoin Capsules, USP 10 mg. Rx Only, 3 Prescription Blister Packs of 10- Capsules Each (30 Capsules)-. Distributed by: Amneal Pharmaceuticals LLC, Bridgewater, NJ 08807. NDC 69238-1174-3
Where it went
Recalled product was distributed to retailers and wholesalers who may have further distribute the product.
How much
2460 cartons/3 blister cards/10 capsules each

Absorica (Isotretinoin) Capsules 30 mg USP, 30 capsules (3x10 Prescription Packs) Rx only, Manufactured by:

D-1207-2019  ·  Class III  ·  reported 2018-12-26  ·  Terminated

Why it was recalled
Subpotent Drug: Isotretinoin content results were lower than the specification limit obtained during routing product monitoring.
Product
Absorica (Isotretinoin) Capsules 30 mg USP, 30 capsules (3x10 Prescription Packs) Rx only, Manufactured by: Galephar Pharmaceutical Research Inc. Humacao, PR 00792, Distributed by: Sun Pharmaceutical Industries Inc. Cranbury, NJ 08512, UPC 310631117313, NDC 10631-117-31 (carton) NDC10631-117-69 (prescription pack)
Where it went
Nationwide in the USA
How much
47,520 prescription packs

Zenatane (isotretinoin) Capsules, USP, 20 mg, 30-count (3 x 10 Prescription Packs) per carton, Rx Only, Manufa

D-0884-2017  ·  Class II  ·  reported 2017-06-14  ·  Terminated

Why it was recalled
Failed Dissolution Specifications: out of specification results observed for low dissolution.
Product
Zenatane (isotretinoin) Capsules, USP, 20 mg, 30-count (3 x 10 Prescription Packs) per carton, Rx Only, Manufactured By: Cipla Limited, Kurkumbh Village, Pune 413802 India, Manufactured For: Dr. Reddy's Laboratories, Bachupally 500 090 India, NDC 55111-136-81
Where it went
Nationwide in the USA and Puerto Rico
How much
89,118 cartons

Zenatane (isotretinoin) Capsules, USP, 10 mg, 30-count (3 x 10 Prescription Packs) per carton, Rx Only, Manufa

D-0883-2017  ·  Class II  ·  reported 2017-06-14  ·  Terminated

Why it was recalled
Failed Dissolution Specifications: out of specification results observed for low dissolution.
Product
Zenatane (isotretinoin) Capsules, USP, 10 mg, 30-count (3 x 10 Prescription Packs) per carton, Rx Only, Manufactured By: Cipla Limited, Kurkumbh Village, Pune 413802 India, Manufactured For: Dr. Reddy's Laboratories, Bachupally 500 090 India, NDC 55111-135-81
Where it went
Nationwide in the USA and Puerto Rico
How much
13,221 cartons

Zenatane (isotretinoin) Capsules, USP, 30 mg, 30-count (3 x 10 Prescription Packs) per carton, Rx Only, Manufa

D-0885-2017  ·  Class II  ·  reported 2017-06-14  ·  Terminated

Why it was recalled
Failed Dissolution Specifications: out of specification results observed for low dissolution.
Product
Zenatane (isotretinoin) Capsules, USP, 30 mg, 30-count (3 x 10 Prescription Packs) per carton, Rx Only, Manufactured By: Cipla Limited, Kurkumbh Village, Pune 413802 India, Manufactured For: Dr. Reddy's Laboratories, Bachupally 500 090 India, NDC 55111-113-81
Where it went
Nationwide in the USA and Puerto Rico
How much
223,650 cartons

Zenatane (isotretinoin) Capsules, USP, 40 mg, 30-count (3 x 10 Prescription Packs) per carton, Rx Only, Manufa

D-0886-2017  ·  Class II  ·  reported 2017-06-14  ·  Terminated

Why it was recalled
Failed Dissolution Specifications: out of specification results observed for low dissolution.
Product
Zenatane (isotretinoin) Capsules, USP, 40 mg, 30-count (3 x 10 Prescription Packs) per carton, Rx Only, Manufactured By: Cipla Limited, Kurkumbh Village, Pune 413802 India, Manufactured For: Dr. Reddy's Laboratories, Bachupally 500 090 India, NDC 55111-137-81
Where it went
Nationwide in the USA and Puerto Rico
How much
452,290 cartons

Zenatane (isotretinoin) capsules, 10 mg, packaged in 30-count cartons (3 x 10 blister cards), Rx Only, Manufa

D-0509-2017  ·  Class III  ·  reported 2017-03-08  ·  Terminated

Why it was recalled
Failed dissolution specifications - low dissolution results at S3 stage.
Product
Zenatane (isotretinoin) capsules, 10 mg, packaged in 30-count cartons (3 x 10 blister cards), Rx Only, Manufactured By:Cipla Limited Kurkumbh Village Pune 413802 India, Manufactured For: Dr. Reddy's Laboratories, Bachupally 500 090 India, NDC 55111-135-81
Where it went
U.S. Nationwide
How much
4404 cartons

Zenatane (isotretinoin) capsules, 40 mg, packaged in 30-count cartons (3 x 10 blister cards), Rx Only, Manufa

D-0506-2017  ·  Class III  ·  reported 2017-03-08  ·  Terminated

Why it was recalled
Failed dissolution specifications - low dissolution results at S3 stage.
Product
Zenatane (isotretinoin) capsules, 40 mg, packaged in 30-count cartons (3 x 10 blister cards), Rx Only, Manufactured By: Cipla Limited Kurkumbh Village Pune 413802 India, Manufactured For: Dr. Reddy's Laboratories, Bachupally 500 090 India,NDC 55111-137-81
Where it went
U.S. Nationwide
How much
4032 cartons

Zenatane (isotretinoin) capsules, 20 mg, packaged in 30-count cartons (3 x 10 blister cards), Rx Only, Manufa

D-0507-2017  ·  Class III  ·  reported 2017-03-08  ·  Terminated

Why it was recalled
Failed dissolution specifications - low dissolution results at S3 stage.
Product
Zenatane (isotretinoin) capsules, 20 mg, packaged in 30-count cartons (3 x 10 blister cards), Rx Only, Manufactured By:Cipla Limited Kurkumbh Village Pune 413802 India, Manufactured For: Dr. Reddy's Laboratories, Bachupally 500 090 India, NDC 55111-136-81
Where it went
U.S. Nationwide
How much
12132 cartons

ZENATANE (isotretinoin capsules USP) 20 mg, 30 capsules per prescription pack, Rx Only, Manufactured by: Cipla

D-0098-2017  ·  Class III  ·  reported 2016-10-19  ·  Terminated

Why it was recalled
Failed Dissolution Specifications
Product
ZENATANE (isotretinoin capsules USP) 20 mg, 30 capsules per prescription pack, Rx Only, Manufactured by: Cipla Limited, Kurkumbh Village Pune 4138012 India, Manufactured for: Dr. Reddy's Laboratories Limited Bachupally 500 090 India, NDC 55111-136-81
Where it went
nationwide
How much
3,858 prescription packs (115,680 capsules)

Absorica (isotretinoin) Capsules, 25 mg, Packaged in 3 x 10 Count Blister Cards/Box, Rx Only. Manufactured fo

D-1288-2015  ·  Class II  ·  reported 2015-08-12  ·  Terminated

Why it was recalled
Incorrect/Undeclared Excipients: Product contains undeclared FD&C Yellow No. 5 in the capsule shell.
Product
Absorica (isotretinoin) Capsules, 25 mg, Packaged in 3 x 10 Count Blister Cards/Box, Rx Only. Manufactured for: RANBAXY LABORATORIES, INC Jacksonville, FL 32257 USA. NDC: 10631-133-31.
Where it went
Nationwide
How much
9,229 Boxes
Read these counts with three things in mind

A firm with more recalls usually makes more products. A contract packer runs hundreds of lines. It will out-recall a company with one product whatever either does. This is not a safety ranking.

Most recalls here are voluntary. A firm found its own fault and pulled the stock. That is the system working. It lands in this database looking the same as a recall the FDA had to push for.

Terminated means the FDA considers the recall finished. It is not a verdict. It does not mean anyone was harmed.

Source: openFDA enforcement reports, retrieved 2026-08-05. FDA dataset last updated 2026-07-29.

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